Collection data of the marine sponge specimens studied; three species: Geodia barretti, Stryphnus fortis and Weberella bursa. Collection data includes locality, depth, salinity, bottom temperature, gear, date, cruise and station# and a collection number for every specimen (DFO Canada collections). NCBI SRA# of the 16S gene amplicon sequencing of their microbiome. Numbers of the UPLC-HRMS runs (four different modes for every specimen: HILIC+, HILIC-, RP+ and RP-). The raw UPLC-HRMS datasets are deposited in the repository metabolights (www.ebi.ac.uk/metabolights/MTBLS1388). QC runs are Quality Control runs for the UPLC-HRMS experiment (also deposited in metabolights).

Sponge specimens were collected in the Davis Strait area between 2011 and 2015 by the crews of the R/V Pâmiut of the Greenland Institute of Natural Resources during cruises conducted by Fisheries and Oceans Canada. Sponges were dredged using Alfredo or Cosmos benthic trawls at depths between 244 m and 1481 m. Collectors on board were Dr. Wojciech Walkusz and Tim Siferd, Fisheries & Oceans Canada (DFO), Central and Arctic Division, Winnipeg, Manitoba, during their multispecies stock assessment surveys.