The Life Sciences Collaborative Access Team (LS-CAT) provides Macromolecular Crystallography support to our CAT members from seven Universities in the USA, including Northwestern University, University of Michigan, Wayne State University, Michigan State University, University of Wisconsin, Vanderbilt University, and University of Illinois at Chicago, and also to General Users. With a one-year dark period approaching for the upgrade of the Advanced Photon Source (APS-U), we sought beam time for our CAT Member laboratories at ESRF by way of a Block Allocation Group Proposal, in order to keep supporting their research and their ability to secure future funding. LS-CAT has organized our CAT Members (~80 PIs and their laboratory personnel) into this BAG Proposal, and in order to streamline the process for our CAT Members, and for the Staff of Lightsources to which we are applying for access to beam time, only LS-CAT Staff Crystallographers will be collecting and managing the data.