This data set contains milling itineraries and granulometric properties of the resulting powders obtained from a collection of by-products from woods (pine wood pellets, pine bark, pine sawdust, Douglas shavings, chesnut tree sawdust) representative of currently used lignocellulosic biomass. The data are gathered in four tables. Table 1 provides a precise description of milling itineraries associated with produced powder samples. Table 2 reports the granulometric characteristics of all produced powder samples. The kinetics of particle size reduction for a subset of produced powder samples are gathered in Table 3. In Table 1, a milling itinerary is described by a set of unit operations and associated with a unique numerical identifier (column Experience number). Each unit operation of a given itinerary is described on a separate line and associated with a unique numerical identifier (columns Experience number + Process step number). Numerical value associated with Process step number column indicates temporal order (e,g step 1 is before step 2). In case of parallel unit operations, a dot is used (e,g step 1.1 is parallel to step 1.2). The following information are reported: date; biomass nature and name (Biomass) ; processing operation type (Treatment); drying mode/moisture content (Treatment); biomass quantity; equipment name and type (Material); rotation speed; vibration frequency; mass of balls; sieving grid size (sieving size); treatment duration; temperature; output solid quantity (Output solid constituent quantity); output solid yield (Output solid constituent quantity), characterized sample product name (Sample Product1). In Table 2, are found the data concerning particles and powders characterization: characterized sample product name (Sample Product); biomass name and nature (Biomass); d50 calculation method; d50 in volume; d50 in number; d10 calculation method; d10 in volume; d10 in number; d90 calculation method; d90 in volume; d90 in number; span; specific surface area calculation method; specific surface area value. Table 3 has the same structure that Table 2 extended by an additional column (Sampling time) indicating the time at which a sample has been extracted during the milling for granulometric characterisation. Table 4 contains the whole set of full particle size distributions of all samples of Table 3. An additional file describres SOP (Standard Operating Procedure) parameter conditions used for granulometric characterization.