The objective of this study was to determine how transcriptomic responses in the spleen and liver are altered in juvenile Paralichthys lethostigma exposed to oil, a known fish pathogen (Vibrio anguillarum), or both. Overall design: P. lethostigma juveniles were exposed to oil, a pathogen (Vibrio anguillarum) or both. Oil exposure was for 8 days and pathogen exposure was for 1 hour, 24 hours before takedown. Oil was from the Macondo well from the Deepwater Horizon oil spill and was mixed with sediment, following established procedures. At the end of the experiments, livers and spleen were taken from organisms, RNA was extracted and sequenced.