Folding and unfolding of model antimicrobial peptides in aqueous solution

DOI

Antimicrobial peptides (AMP) are naturally occurring biomolecules which act as a defense mechanisms against disease in a number of different animals, including humans. These peptides often fold into helices which can penetrate into a wide range of microbial membranes and are of recent interest due to their potential as treatment for infectious diseases. AMP helices have a unique as secondary structure: the peptide fold in such a way that one surface of the helix is hydrophobic whilst the other is largely hydrophilic, in principle this arrangement 'matches' the amphiphilic environment presented by biological membranes so that these AMP can easily penetrate across this barrier. Here we propose to investigate the structure of model AMPs in aqueous solutions in order to understand the role of solvation for AMP behaviour in solution.

Identifier
DOI https://doi.org/10.5286/ISIS.E.60998788
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/60998788
Provenance
Creator Dr Ric Gillams; Ms Nicola Steinke; Dr Sylvia McLain
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Natural Sciences
Temporal Coverage Begin 2015-07-15T07:36:46Z
Temporal Coverage End 2015-07-19T07:59:00Z