Amphiphilic copolymers with perfluoroalkyl blocks provide self-assembled nanostructures, in water, via the association and/or self-folding of the copolymer chains. This feature can be used for "green nanochemistry" or to design drug delivery systems. The folding of single chains of a block copolymer into nanoparticles has been assessed by dynamic light scattering (DLS) and by SANS2D Xpress experiment. Such polymers have an additional attractive feature: the polymer displays a self-assembly process not far from physiological temperature. DLS results indicate a sharp transition temperature with the formation of monodisperse particles with size distribution centered around 1 micron. In the proposed experiment the surface of the particle (roughness, block distribution) around the transition temperature will be investigated to optimize the association or the coupling with functional molecules