The aim of this proposal is to provide user access to automated protein-to-structure and fragment screening pipelines based on the combination of EMBL HTX lab services and CrystalDirect technology and automated data collection at ESRF’s MX beamlines. Access modalities will include 1) Online-Crystallography (Protein-to-Structure pipeline) 2) Large-Scale ligand and Fragment Screening and 3) new Plate-to-beam data collection modalities enabled by the integration of CrystalDirect at MASSIF1. User access to these modalities will require competitive application and peer-review through the E.C. funded iNEXT Discovery and Instruct-ERIC consortia. Moreover, new approaches for high density ligand screening will be implemented and the experimental opportunities enabled by the Integration of CrystalDirect at the MASSIF-1 station will be further developed. This work will be carried out in the context of international collaborative projects.