Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering AMPs to bacteria infected regions within the body and hope to now study the mechanism and kinetics by which LS3 (our chosen AMP) interacts with a biological system. Moving eventually towards building an understanding of the route to ion channel formation through voltage induced 'flipping'. In this first experiment beginning a series of work with a new PhD student, we plan to use selective deuteration of the bilayer and peptide to derive the mechanism of LS3 insertion from solution and rearrangement into the outer leaflet of the membrane. We have shown using other techniques that insertion can occur from solution and intend to use the neutron reflectivity data to give accurate kinetic & positional information.