Time-resolved SANS will be performed to investigate the effect of shear on the fibrillisation of insulin following denaturation. The rheological response will be measured simultaneously. The measurements will be performed with the new Physica rheometer available on LOQ. The insulin will be thermally denatured at pD 2 in acid D2O to minimise background and to improve contrast. The kinetics of fibrillisation will be studied under shear at different rates and compared to the static fibrillisation kinetics. Shear at moderate shear rates is expected to enhance fibrillisation, although breakup of fibrils may be observed at higher shear rate. The project is related to the CCLRC Centre for Molecular-Structure and Design sponsored studentship in a collaboration between Ian Hamley (Reading), Steve King (ISIS) and Nick Terrill (Diamond)