At a recent experiment at the ILL using D22, we made an incidental observation that addition of hydrophilic silica (SiO2) nanoparticles (NP; D~14 nm) induced alignment in the lipid mesophase consisting of 85%:15% monoolein:D2O within a certain temperature range (40 ¿ 80 oC), at a minute NP:lipid number ratio 1e-6, i.e., 1 NP per 1 million lipid molecules. Here we propose a combined study for both the high-Q-resolution mesophase determination, and small angle scattering to unravel the distribution of NP in the mesophases by contrast matching deuterated-hydrogenated lipids with D2O/H2O surrounding. We will systematically vary the lipid composition, NP size D and number ratioOur results will provide mechanistic insight for such peculiar NP induced mesophase alignment, with implications to nanocomposite materials and fundamentals of nanotoxicology.