This project collects the genomic and transcriptomic data generated for Sepiola affinis to facilitate genome assembly and annotation as part of the Aquatic Symbiosis Genomics (ASG) Project (https://www.aquaticsymbiosisgenomics.org/) from samples supplied by the ASG Genomic-Signatures Hub (https://www.aquaticsymbiosisgenomics.org/collaborators/genomic-signatures-behind-the-origin-of-multiple-cephalopod-symbiotic-organs/). The data under this project are made available subject to the Tree of Life Open Data Release Policy (https://www.darwintreeoflife.org/project-resources/).