The highly-elevated and flat Altiplano in Peru is a remarkable landscape feature in such metastable geomorphologic context. However, the northern edge of the Peruvian Altiplano, namely the Abancay Deflection, is widely dissected and incised by two hydrographic networks belonging to the Apurimac and Urubamba rivers draining toward Amazonia crossing through the Eastern Cordillera. Exploring the Abancay Deflection region with geomorphologic tools permits to discuss the paleo-landscape context and the active tectonic settings of this area. This dataset is composed of knickpoints and knickzones locations extracted in the Apurimac and Urubamba watersheds. We extracted knickpoints in the Abancay deflection using the Matlab module ChiProfiler (Gallen & Wegmann, 2017) implemented in Topotoolbox v.2 (Schwanghart & Scherler, 2014). We analyzed 752 rivers for the Urubamba watershed and 553 for the Apurimac watershed. For each river, we manually selected the knickpoints. We classified them in four categories given their vertical offset: A > 0,5 km; 0,25 < B < 0,5 km; 0,1 < C < 0,25 km; D < 0,1 km. Each knickpoints extracted correspond to the upstream of the slope rupture at the inflexion point of the river profile considered. We then categorized the origins of these knickpoints (moraine, glacial lock, edge of a perched surface) by identifying them on the field, on Google Earth Pro images and geological maps from INGEMMET (1/50 000 and 1/100 000; http://geocatmin.ingemmet.gob.pe/geocatmin/). This catalogue is not exhaustive because we did not analyze all rivers, but we performed the extraction to cover the study area the most homogeneous and objectively as possible.