-
Molecular architecture of novel, trichain-containing vectors for gene delivery
We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first... -
Smart dendrimersomes for biosensing and triggered delivery
Dendrimersomes are an exciting new class of vesicles, comprising bilayers of dendrimer molecules that can be engineered to have sensitivity to e.g. changes in pH and enzymes.... -
Study of the interaction of various LPSs with Lactoferrin.
Proposal is focused on the study of the interactions of some lypopolysaccharides (LPSs) with Lactoferrin. LPSs compose about 70-80% of the outer membrane of Gram negative... -
More realistic models of the bacterial outer membrane
Current model systems employed in structural studies of bacterial outer membranes rarely mimic the lipid composition accurately. This work is aimed at producing outer membrane... -
The calcuim mediation interaction of DNA with monolayers of DSPC and DOPE
The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper... -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
Floating Bilayer Mimics of the Gram Negative Bacterial Outer Membrane
The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will... -
Molecular interactions between phospholipid monolayers and dimethylsulphoxide
Neutron reflectivity will be employed to investigate the interaction between dimethylsulphoxide and monomolecular films of phosphatidylcholine. The monolayer will be used as a... -
The hydration of the DOPE lipid headgroup
Understanding how water hydrates cellular membranes is an important aspect of understanding how water-soluble compounds - such as drugs - can cross into a cell from the blood...
