499 emerging chemicals (ECs) were investigated in 56 effluent samples from 52 European wastewater treatment plants (WWTPs). The samples were collected between August 2017 and April 2019, using on-site large volume solid phase extraction (LVSPE) (Schulze et al., 2017). Chemical target screening by liquid chromatography high-resolution mass spectrometry (LC-HRMS) resulted in 366 detected compounds. Different capacities and conventional treatment technologies, as well as two advanced treatment technologies are included. One sample was taken at a WWTP with activated carbon (AC) treatment. Three WWTPs applying ozonation were sampled before and after this treatment step, providing two samples each. One of these WWTPs had already been sampled before the upgrade, resulting in a total of 56 (52+4) samples. More information can be found in Finckh et al. (2022). The two main objectives were (1) to extend our knowledge on chemicals occurring in treated wastewater, and (2) to identify and prioritize compounds of concern based on three different risk assessment approaches for the identification of consensus mixture risk drivers of concern.