This dataset compiles sex-specific survival, fecundity, and physiological data of the marine calanoid copepod Acartia tonsa following a five-day exposure period to the isolated and combined effects of hypoxia and marine heatwave events, in a laboratory set-up. In more detail, the data bundle includes: 1) Daily measurement of the physico-chemical parameters of the seawater for each aquarium holding the copepods during the five-day exposure period, 2) Sex-specific survival data corresponding to the percentage of females and males alive at the end of the five-day exposure period, 3) Total fecundity at the end of the five-day exposure period, represented by the total number of offspring spawned by all females reared in an aquarium, 4) Sex-specific physiological data, in which routine metabolic rates (individual and specific), upper thermal limit, length, and dry weight are reported, following the five days exposure period to the isolated and combined effects of hypoxia and marine heatwave events.