Multi-region scRNA and scTCR data on ADAPTeR patient cohort

DOI

scRNA and scTCR data for the manuscript 'Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma'Samples: Tumour infiltrating lymphocyes taken from two ccRCC patients post anti-PD-1 (nivolumab) treatment. One responder patient, one non-responder patient. For each patient cells were split by IgG4 binding (IgG4 = proxy for nivolumab binding), followed by 10x paired scRNA and scTCR sequencing.Data analysis: sequencing files were demultiplexed and mapped to the hg38 genome and VDJ reference using cellranger count and cellranger vdj respectively. Expression matrices and VDJ annotations are provided in this submission. Also provided is cell metadata containing UMAP co-ordinates and other information pertinent to this study.Files types: .mtx, .tsv, .csvFIle size (compressed) 183.5MB

Identifier
DOI https://doi.org/10.5522/04/16573640.v1
Related Identifier https://ndownloader.figshare.com/files/30665975
Related Identifier https://ndownloader.figshare.com/files/30701183
Metadata Access https://api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:figshare.com:article/16573640
Provenance
Creator Beattie, Gordon; Au, Lewis; Hatipoglu, Emine; Robert De Massy, Marc; Litchfield, Kevin; Schnidrig, Desiree; Thompson, Rachael; Byrne, Fiona; Horswell, Stuart; Fotiadis, Nicos; Hazell, Steve; Nicol, David; Shepherd, Scott; Fendler, Annika; Mason, Robert; Del Rosario, Lyra; Edmonds, Kim; Lingard, Karla; Sarker, Sarah; Mangwende, Mary; Carlyle, Eleanor; Attig, Jan; Joshi, Kroopa; Uddin, Imran; D. Becker, Pablo; Werner Sunderland, Mariana; Akarca, Ayse; Puccio, Ignazio; Yang, William; Lund, Tom; Dhillon, Kim; Vasquez Duran, Marcos; Ghorani, Ehsan; Xu, Hang; Spencer, Charlotte; Lopez, Jose; Green, Anna; Mahedeva, Ula; Borg, Elaine; Mitchison, Miriam; Moore, David; Proctor, Ian; Falzon, Mary; Pickering, Lisa; Furness, Andrew; Reading, James; Salgado, Roberto; Marafioti, Teresa; Jamal-Hanjani, Mariam; Kassiotis, George; Larkin, James; Swanton, Charles; Chain, Benny; Quezada, Sergio; Turajlic, Samra
Publisher University College London UCL
Contributor Figshare
Publication Year 2021
Rights https://creativecommons.org/publicdomain/zero/1.0/
OpenAccess true
Contact researchdatarepository(at)ucl.ac.uk
Representation
Language English
Resource Type Dataset
Discipline Other