There are at least a dozen small hyper-turbid estuaries facing the Bay of Biscay, geographically situated between the two major estuaries of the Gironde and the Loire. MAGEST and SYVEL high-frequency multi-site monitoring revealed that the Loire, and to a lesser extent the Gironde, are subject to summer hypoxia. These observations raised the question of the potential occurrence of hypoxia in the small estuaries in between, motivating an investigation of dissolved oxygen in one of them, the Charente estuary. Oxygen and salinity sensors were placed at L'Houmée (2019), Tonnay-Charente (2018; 2019), Rochefort (2020; 2021; 2022), Martrou (2020) during summer, the most critical period for dissolved oxygen; a multiparameter probe was placed at Tonnay-Charente from April to November 2020. Longitudinal investigations along the estuary axis were also carried out during the summers of 2018 and 2019. All the measurements were acquired at 0.5 ± 0.2 meters below the surface. The dataset enabled us to identify the occurrence of summer hypoxia and an oxygen depletion zone in the Charente estuary. These results resulted in the implementation of high-frequency monitoring at Tonnay-Charente, operational since November 2020.