The Sr and Nd isotope composition of the siliciclastic sediment fraction of the marine sediment core GeoB22336-4 from the mouth of Lancaster Sound, northern Baffin Bay, were analyzed to identify changes in sediment provenances during the late Pleistocene and the Holocene. Sample preparation and radiogenic isotope analyses were conducted in the laboratories of the Isotope Geochemistry Group at MARUM – Center for Marine Environmental Sciences, University of Bremen, Germany. To isolate the siliciclastic sediment fraction, sediment samples were leached with a NaOH-buffered solution of hydroxylamine hydrochloride and 15% acetic acid (adapted from Gutjahr et al. 2007, https://doi.org/10.1016/j.chemgeo.2007.03.021). Nd and Sr were separated by column chemistry, and the isotope ratios were measured with a Thermo-Fisher Scientific TRITON Plus thermal ionization mass spectrometer (TIMS). More details on radiogenic isotope analyses can be found in the related paper (https://doi.org/10.1016/j.quascirev.2023.108101).