15 datasets found

It is difficult for the naked external gene to become internalized due to its similar charge to the extracellular membrane surface. Various cationic copolymers and cationic...

We have previously used LOQ to identify the complex (polyplex) structures formed between a short single strand DNA and a cationic diblock copolymer MPC30-DEA60. The SANS...

We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing...

In many applications, surfactants are formulated with a variety of additives to achieve a desired range of properties; polymers and cosurfactants/cosolvents (such as alcohols)...

For polymer vesicles to act as effective molecular delivery systems we must efficiently encapsulate a molecular payload within the vesicle. We would like to use neutron...

Polyurethane foams (PUFs) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agent...

Aliphatic polyesters are the most attractive candidates for biodegradable polymers. To improve their physical properties while maintaining biodegradability, incorporating...

We have recently studied the surface segregations of amphiphilic block copolymers blended in a matrix of cross-linked poly(dimethyl siloxane). In this system, while the...

The key to the use of polymer vesicles as effective molecular delivery systems is in the ability to efficiently encapsulate a molecular payload within the vesicle. We would like...

The use of polymer-drug conjugates for the delivery of drugs to specific sites of disease within the body has shown much clinical promise. It has become clear that the...

In this work we will study a novel block copolymers consisting of a linear cationic block and uncharged bottle-brush block having 45 units long poly(ethylene oxide) side chains....

We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing...

We intend to use small angle neutron scattering to investigate the conformational behaviour of a range of amphiphilic copolymers comprising a hydrophobic methacrylate segment...

The proposal aims to determine the degree of interfacial mixing and roughness at an interface between two conjugated polymers, as part of a broder program to understand how to...

Polymer therapeutic describes polymeric drugs, polymer-drug conjugates, polymer-protein conjugates, polymeric micelles to which drug is covalently bound, and multicomponent...