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Effect of saponin-rich plant extracts on skin-mimicking model lipid bilayers
Plant-derived biosurfactants of the group of saponins offer an attractive alternative to synthetic surfactants because of their unique foaming and emulsifying properties... -
Evolution of raft formation over time using contrast variation SANS
Small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect the presence and size formation of lipid microdomains or... -
Ligand induced changes of the 18kDa translocator protein in a lipid bilayer
The proposed experiments will investigate conformational changes of the 18kDa translocator protein (TSPO) in a lipid bilayer using neutron reflectometry at the solid-liquid... -
SANS studies of phospholipid:sterol vesicles and the membrane interactions of...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Nanophase separation in monolayers of stratum corneum mixtures
There is considerable effort being put into the modelling of the outer layer of skin, the stratum corneum, because of impending EU restrictions on the use of animal skin for... -
The hydrophobic interaction A peptides and a lipid monolayer at the o...
This proposal relates to the study on the fundamental level, the hydrophobic interaction A peptides and a lipid monolayer at the oil-water interface. NR will be used to... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Conformation of lipid, DSPC and cholesterol mixture
In this proposal we intend to investigate the intermolecular interactions in a mixed phospholipid/cholesterol monolayer at the oil-water interface using neutron reflectometry.... -
Neutron reflectivity study of bacterial lipopolysaccharide interactions with ...
Bacterial LPS (endotoxin) is a key determinant of host/pathogen interactions. We propose to investigate the role of membrane lateral phase separation on LPS insertion into model... -
Selective recruitment of cholesterol to lipid rafts by multivalent protein bi...
Lipid raft microdomains offer a means to enhance the local concentration of membrane components as well as serve as a platform for raft associated endocytosis. Driven by... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Structure of Meibomian lpid films at the air-water interface using
The tear film of the eye has an outer meibomian lipid layer (TFLL) that allows tears to spread across the eye and remain stable. Our Langmuir trough and other studies show that...
