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Structure of lipid monolayers following oxidative damage
Lipids form the major component of cell membranes, which separate the contents of the cell from the external environment. The oxidation of lipids within biological membranes is... -
Lipid bilayers suspended beneath the air/water interface for neutron reflecti...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,... -
Changes to the structure of natural lung surfactant following OH(aq) radical ...
The presence of lung surfactant at the air-water interface of the lung is vital to prevent alveolar collapse. Exposure to environmental pollutants can cause the formation of... -
Elucidating the effect of BTHC on DMPC monolayers
Plastic bags are used as containers for storage of donated blood. These bags are often made of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into the blood... -
Effect of squalene on membrane structure and Amphotericin B resistance in Can...
The yeast Candida glabrata is becoming an increasing cause of infections. We have developed RNA interference tools that allow us to study the virulence and resistance mechanisms... -
Multilayering of Methyl Ester Sulphonates at the Air-Aqueous Interface: Effec...
Surfactants usually form a single layer of molecules at the surface of water. We have shown that under certain conditions more than one layer may form. When this happens the... -
Binding studies of Quantum Dots and Pore-Forming Proteins on multi-component ...
Cell membrane being the first line of defence of a complex cell, it forms an important scientific topic to study its encounter with various external entities. Nanoparticles are... -
Interfacial structures and competitive adsorption of amphiphilic millipede po...
Foam stability, appearance and functionality is governed by the thin liquid films between foam bubbles. These films are stabilised by surface active molecules (surfactants and... -
Ibuprofen containing surfactant monolayers: location and stiochiometry of ibu...
An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a... -
The origins of Biosurfactant self assembly
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Determination of the absorbed amount and location of a hydrophobic drug in su...
Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of... -
The structure of glycerol mono oleate at the iron oxide/dodecane interface
The reliability of combustion engines is enhanced by lubrication, which provides wear protection along with reduced emissions and fuel consumption through the minimisation of... -
Lipid bilayers suspended beneath the air/water interface for neutron reflecti...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,... -
More than the sum - oxidation behaviour of mixed fatty acid monolayers
Single molecule thin films of various surface-active species are found on the surface of water bodies from the sea down to microscopic spray droplets. These films affect the... -
Interaction of lignosulphonates with model surfactant systems by neutron refl...
With the biobased economy growing substantially and pressure to reduce reliance on palm and crude oil derived materials, it is vital that the Home and Personal Care industry... -
Structures of cardiolipin-bound cytochrome c in pathological conditions
Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner mitochondrial membrane, which is known to provide essential structural and functional... -
Autoxidation vs. Ozonolysis of Surfactant Mixtures Containing Poly-unsaturate...
Surface-active molecules with water-loving and water-hating parts have been found to contribute substantially to the man-made urban aerosol load originating from cooking... -
Amino-Acid Based Surfactant Monolayers on a Range of Subphases
Amino acid based surfactants have been known for many years but so far few detailed studies have been carried out on their properties. We are using amino acids extracted from... -
Mixed Amino-Acid Based Surfactant Monolayers
Amino acid based surfactants have been known for many years but so far few detailed studies have been carried out on their properties. We are using amino acids extracted from... -
Tuneable Creation of Reservoir Structures at the Air/Water Interface
Recently we have exploited non-equilibrium effects in the preparation of super-efficient polyelectrolyte/surfactant films at the air/water interface spread from the dissociation...