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Germline mutation rate in vertebrates
We estimated the germline mutation rate of 68 species of vertebrates using WGS of pedigrees (i.e. at least 3 individuals mother, father, and their offspring). -
Using transcriptomics and metabolomics to understand species differences in s...
Modern 21st century toxicity testing makes use of omics technologies to address critical questions in toxicology and chemical management. Of interest are questions relating to... -
Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Sex in birds is genetically determined, molecular mechanism of which is not well-understood. Their Z sex chromosome (chrZ) lacks whole chromosome inactivation as known for... -
EcoToxChip 2016 LSARP RNASeq database
As part of the EcoToxChip project, 49 distinct exposure studies were conducted on three lab model species (Japanese quail, fathead minnow, African clawed frog) and three... -
Evolution of the Hypothalamus
The purpose of our project is to understand the evolution of the hypothalamus across major vertebrate classes. The hypothalamus has been well conserved across evolution and... -
A cross-species analysis of microRNAs in the developing avian face
Avian beaks show extreme species-specific variability in morphology, though they develop from the same primordial structures. In both humans and birds, cranial neural crest...