-
Biochemically diverse CRISPR-Cas9 orthologs
CRISPR-Cas9 nucleases are abundant in microbes. To explore this largely uncharacterized diversity, we applied cell-free biochemical screens to rapidly assess the protospacer... -
Recovery of high-quality assembled genomes via single-cell genome-guided binn...
High-quality (HQ) reference genomes are essential for understanding the phylogeny and function of uncultured microbes in complex microbial ecosystems. However, existing...