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Understanding domain organization in a binary lipid mixture by SERGIS
Membranes of cells are the physical barrier between the inside and outside of the cell. Transport and signaling is control by transport and signaling proteins but their ability... -
Molecular architecture of vesicles formed by novel sterol-modified phospholipids
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Microdomains in model membranes using contrast variation SANS
In the present proposal small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect the presence and size formation of... -
Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
The hydrophobic interaction A peptides and a lipid monolayer at the o...
This proposal relates to the study on the fundamental level, the hydrophobic interaction A peptides and a lipid monolayer at the oil-water interface. NR will be used to... -
Chloride Intracellular Channel insertion into Tethered Bilayer Membranes
Part One of the proposal is concerned with the fundamental structure of the TBM and aims to determine: (i) the impact of spacer molecule length on the dimensions of the bilayer... -
Understanding Phospho-L-Serine (PS) role in the Organization of Cholesterol C...
Our goal is to understand the role of POPS, a lipid component only found in the inner leaflet of plasma membrane, in the organization of cholesterol in cell membranes. Our... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Effect of method of preparation on the composition of complex monolayers
In the present proposal neutron reflectivity will be used in combination with contrast variation to detect changes in the presence (and size) of microdomains in monolayer films...