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Interplay of apoptosis regulating Bcl-2 proteins with mitochondrial membranes...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
Oxidation of gram-negative cell-wall proxy with OH radicals - kinetics and me...
Hydroxyl radicals may be used as disinfection agent in the advanced oxidation processes or tertiary treatment of waste and occasionally drinking water. We very recently oxidised... -
Tuneable Adsorption of Soft Colloids on Model Biomembrane
Understanding how nanoparticles interact with lipid bilayers will potentially have high impact on the development of new drug delivery systems, and on the investigation of their... -
Correlations between local magnetism and spin-orbit transport physics in topo...
One of the main challenges in spintronics research is to provide a link between magnetic elements and conventional electronic circuits. A novel approach to this old problem is... -
Influence of the polarity of plasticizer and degree of hydrolysis of Poly-Vin...
Migration of small molecules to, and across the surface of polymer matrices is a little-studied problem with important industrial applications. PVAc films are of industrial... -
Hydrogen kinetics in nano-layered metal hydrides for hydrogen sensing applica...
Accurate, safe and cheap hydrogen detectors functioning under a wide range of conditions are a vital ingredient for using hydrogen as an energy carrier. A novel, safe and cheap... -
Swelling of Single Supported Bilayers ¿ First Systematic Investigation of the...
This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Polyoxometallate surfactant adsorption at solution surfaces
Polyoxometallates (POM) are well defined transition metal clusters with a range of interesting catalytic, magnetic and optical properties. To make efficient use of these... -
Protein exchange at the solid/liquid interface
The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins... -
Using the nano discs approach at surfaces to determine the relation between s...
Membrane bound proteins continue to be to date the most elusive molecules in nature, since they are only functional in the lipid bilayer. We have developed a method to study... -
Understanding the insertion of antibiotic toxins into the gram negative outer...
The gram-negative bacterial membrane is of extreme medical importance. Two of its major components are lipopolysaccharides (LPS's) and integral membrane proteins. Porins are... -
Magnetic moment of EuO in spin filtering magnetic tunnel structures
EuO is the ferromagnetic oxide semiconductor with the highest demonstrated value of conduction band exchange splitting (0.6 eV), which makes it at present one of the most... -
pH-Responsive Polyelectrolyte Brushes Studied by Neutron Reflectivity and in ...
pH-responsive polymer brushes comprise of long polymer chains of either a weak acid or base chemically attached to a surface. Depending upon the degree of ionisation along the... -
Polymerisation of Styrene in PEI-Surfactant Films on Si Wafers
We have been studying the formation of solid polymer-surfactant films formed from cationic surfactants with PEI. We wish to use the highly organised mesostructures formed in the... -
Antibiotic binding to a bacterial outer membrane model containing oriented pr...
The Outer Membranes (OM) is a feature of many pathogenic bacteria. It is important as a barrier to antibiotics & the site of human-bacteria interaction. However bacteria are... -
The role of disulphide bridges in the adsorption of globular proteins at the ...
Following our previous study of adsorption of globular lysozyme and BSA at the oil/water interface by neutron reflection, we continue to explore how unfolding of globular... -
Membrane reconstitution of human dihydroorotate dehydrogenase using lipid-det...
Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with... -
Spatially profiling internal microstructure changes during redox driven rapid...
The redox driven swelling and deswelling of conducting polymers has been termed Electronic Muscle actuation. One application of this property is as a sphincter-like valve in a... -
Co-surfactancy of oil-soluble and water-soluble surfactants at the oil-water ...
A technique we have recently developed enables us to simply produce stable, homogenous and thin oil layers, using polymer surfactants, in a simple manner on water. These are...