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Self-assembly of protein polymer conjugates: Effect of copolymer structure
Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation or crosslinking resulting in lack of... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Probing binary mixtures of hard spheres
As part of a larger programme we aim to test densely-packed binary mixtures of monodisperse hard sphere powders to determine local structure, to correlate with ratio of... -
How do Polymer Stabilized Nanodiscs Form?
Nanodiscs are self-assembled structures composed of phospholipids stabilised by a polymer belt. They are capable of encapsulating single membrane proteins and as such have many... -
Structure of Cellulose Nanofibril Gels with Alcohols
Our group has been working partially oxidized cellulose nanofibrils which form gels in aqueous formulations. Recently we have observed that these fibrils also gel when dialysed... -
Lipid-polymer nanodiscs stabilized with amine-based polymers
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies and biophysics. Previously we have studied nanodisc... -
Structure and Water Binding in Natural Deep Eutectic Solvents
Deep Eutectic Solvents (DES) are molecular mixtures similar to ionic liquids, having melting points below room temperature. However instead of being composed of a salt, the... -
Adsorption of Membrane-Protein Containing Nanodiscs at Lipid Interfaces
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Poly(Styrene-Maleic Acid) stabilized lipid nanodiscs can be... -
Silica binding to nonionic micelles: effect of headgroup size
This proposal continues our research on ion binding to surfactant micelles. Our recent work demonstrates that the details of water structure around micelles are now accessible... -
Interpreting the Effect of Small Ions on Charged Lipid Membranes
We propose a study to extend the understanding of the influence of salt on the structure of DPPG membranes floating on an al-PC bilayer. We have previously demonstrated the... -
Ion mediated surfactant adsorption on cellulose films
In recent work with Unilever we have been investigating the structure of gels formed by partially oxidised cellulose nanofibrils for use in sustainable personal care products.... -
Probing binary mixtures of hard spheres
As part of a larger programme we aim to test densely-packed binary mixtures of monodisperse hard sphere powders to determine local structure, to correlate with ratio of... -
Lipid-polymer nanodiscs: Effects of tail length
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Poly(Styrene-Maleic Acid) stabilized lipid nanodiscs have a... -
Pickering emulsions stabilized with oxidised cellulose nanofibrils: Effect of...
Our group has been working partially oxidized cellulose (oxcel) nanofibrils which form gels in aqueous formulations. Recently we have observed that these fibrils can be used to... -
Atomic structure of an isooctane/AOT/water reverse micelle
Micelles and reverse micelles have been studied for a long time using small angle scattering techniques. Information extracted from such studies might typically be in the form... -
Lipid-polymer nanodiscs stabilized with novel sytrene-maleic anhydride derive...
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied nanodisc formation... -
Phase behaviour of di and triblock eGFP-copolymer conjugates in aqueous media
Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation or crosslinking resulting in lack of... -
Ion mediated surfactant adsorption on cellulose films
In recent work with Unilever we have been investigating the structure of gels formed by partially oxidised cellulose nanofibrils for use in sustainable personal care products....
