This file contains the data used in the manuscript "Indigenous Peoples and local communities report ongoing and widespread climate change impacts on local social-ecological systems", by V. Reyes-García et al. Under review in Communications Earth & Environment. Data were collected using a place-specific but cross-culturally comparable research protocol to document climate change indicator and impacts as locally experienced and to analyze their distribution. The dataset includes first-hand data in 48 sites inhabited by Indigenous Peoples and local communities and covering all climate zones and nature-dependent livelihoods. It documents 1,661 site-agreed reports of changes corresponding to 369 indicators.