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Molecular architecture of novel, trichain-containing vectors for gene delivery
We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first... -
Towards optimised detergency at low temperatures
This proposal is about the development of sustainable detergency based formulations, based on the blending of biosurfactants with conventional surfactants, and is part of a CASE... -
Structural studies of mixed anionic and cationic surfactants at the charge me...
This proposal is concerned with the structural study of anionic and cationic surfactant mixture on a charged metal oxide surface using neutron reflectivity. Also to evaluate the... -
How perfume structure affects surface coadsorption with anionic surfactants
In a recent EPSRC / Unilever / Oxford CASE project we have used NR to explore and develop optimised delivery mechanism for active benefit agents such as perfumes. In particular... -
The interaction of oxidatively damaged lung proteins with anionic lipids
Lung surfactant protein B, SP-B, interacts with lipids at the air-water interface of the lung where its presence is vital for correct respiratory function. SP-B and its... -
Interactions between a mixture containing two cationic polyelectrolytes and a...
Recently there has been a vast expansion in understanding about the interactions between oppositely charged polyelectrolyte/surfactant mixtures. The use of neutron reflectometry... -
Multilayer surfactant adsorption onto cellulose surfaces
Studying surfactant and mixed surfactant adsorption on model solid surfaces, which mimic real surfaces such as fabrics, hair and skin, is starting to provide a real insight into... -
Metal ion induced condensation of anionic fluorine-based conjugated polyelect...
In the proposed experiments we aim to characterise the structures of aggregate species formed when divalent metal ions, such as calcium(II), interact with the anionic conjugated... -
Novel block bottlebrush polyelectrolytes: The effect of cationic block charge...
In this work we will study a novel block copolymers consisting of a linear cationic block and uncharged bottle-brush block having 45 units long poly(ethylene oxide) side chains.... -
Complex evolution of solution microstructure in LAS / nonionic surfactant mix...
This proposal is part of a broad programme of collaborative research between RAL / Oxford and Unilever, using predominantly scattering techniques to investigate the nature of... -
Kinetics of surfactant multilayer formation / dissolution at interfaces
The spontaneous formation of multilayer structures at surfaces and interfaces from self-assembly in mixed surfactant and in polymer / surfactant mixtures are being increasingly... -
The effect of anionic lipid unsaturation on the interaction with cytochrome c
While peripheral membrane protein-lipid interactions were originally considered to be solely electrostatic in nature, it is now accepted that they encompass more complicated,... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
Investigation of the surface structure of anionic surfactants induced by the ...
This proposal is part of a major EPSRC (EP/GR065705) / Unilever funded programme to develop and control the spontaneous formation of surfactant multilayer structures at... -
Aggregation behaviour of aqueous hairy rod conjugated polyelectrolyte/surfact...
Small angle neutron scattering (SANS) will be used to characterise the structures of aggregates formed between the anionic conjugated polyelectrolyte... -
Evolution of complex surface structures in LAS / nonionic surfactant mixtures
This proposal is part of a broad programme of collaborative research between RAL / Oxford and Unilever, using predominantly scattering techniques to investigate the nature of... -
Spontaneous surfactant multilayer formation at interfaces induced by multival...
The spontaneous formation of multilayer structures at interfaces from surfactant self-assembly is now emerging as an important structural signature associated with a wide range...