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Startup and Calibration
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Heterogeneous protein exchange at the solid/liquid interface using deuterated...
The formation of protein layers on surfaces is important for medical implants and for the consequences of the ingestion of nanoparticles. In the body, a surface is exposed to a... -
Protein exchange at the solid/liquid interface
The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins... -
Impact of homo- and hetero-association of complex molecular nano-sized drug d...
The present proposal concerns a PEGylated, hydrophobic drug containing polylysine dendrimer that demonstrates unexplained batch-to-batch variability in that two batches of the... -
Nature of the protein corona on nanoparticle surfaces
When nanoparticles enter a biosytem they rapidly acquire a protein corona. The nature of the outer part of this corona will determine the response of the biosystem to the... -
The effect of fatty acids on the adsorption of HSA at the silica water interface
The primary biological function of albumins is to be fatty acid carriers. The complexation of fatty acids to the albumin is expected to have a strong effect on its adsorption... -
Dynamic Adsorption of the Fusion Protein HSA-NEP at the Silica-Water Interface
HSA-NEP is a fusion protein with potential uses in treating Alzheimers disease. It consists of Neprilysin, a peptide degrading enzyme, linked to HSA, the most common protein in... -
The Kinetics of Self-Exchange of a Protein at Solid/Liquid interfaces
The formation of a protein corona occurs on all surfaces exposed to biological systems and understanding of how this corona forms is vital for many aspects of medicine and for... -
Competitive and cooperative adsorption of lysozyme and human serum albumin
All solid surfaces in contact with biological systems form a protein corona and the nature of this corona determines the further response of the biosystem to that solid surface... -
Lagtimes in the adsorption of proteins at the air/water interface
Adsorption of proteins at all surfaces has a characteristic lagtime which can be monitored by surface tension at the air/water interface. The cause of the lagtime is not... -
The effect of phospholipid on the adsorption of HSA at a solid surface
As part of a project concerning the fate of nanoparticles in the body we have been studying the kinetic and competitive (or cooperative) aspects of protein adsorption. HSA is... -
The Interactions of Blood Components with Models of the Gram Negative Bacteri...
One of the major challenges in the fight against antimicrobial resistance is the development of antimicrobial compounds that selectively disrupt bacterial membranes and leave... -
Kinetics of protein and protein mixture adsorption at the air/water interface
Many proteins exhibit a lag in lowering the surface tension at the air-water interface. The origin of this lag is not well understood either experimentally or theoretically. The...