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Structural examination of self-assembled floating membranes below grafted lip...
Robust, reliable, and protein-free bacterial membrane mimicking systems compatible with the high through put screening techniques will largely facilitate the discovery of new... -
Effect of formulation method and lipid composition on liposome lamellarity
Liposomes are vesicles comprising a phospholipid membrane bilayer around an aqueous core. They are well-established in the fields of drug delivery and diagnostics. To translate... -
Quantification of water distribution in chalk/pile interface after pile insta...
Carbon emissions, from electricity generation, is a significant contributor to global warming. With wind power maturing as a sustainable source of clean energy, wind farms are... -
Interaction of an antimicrobial peptide from Lactobacillus gasseri supernatan...
A short peptide, composed of 12 amino acids (EFVFVAHAVPVM), presenting a strongly hydrophobic character, was recently isolated from Lactobacillus gasseri supernatant (AMP12).... -
Structure of lipid monolayers following oxidative damage
Lipids form the major component of cell membranes, which separate the contents of the cell from the external environment. The oxidation of lipids within biological membranes is... -
Probing Water Structure in the Hydration layer around Poly(ethylene glycol)
Water is the source of life, but the effects of hydration water on the conformation change and function of biological and bio-compatible macromolecules are still full of... -
Influence of Alkyl Chain Fluidity on the Membrane Binding Activity of Cationi...
Skin becomes a target of drug delivery because the transdermal routes are non-invasive, can be self-administrated, improves patient compliance and can provide a release for long... -
Molecular interactions and protein stability in the accessory gene regulator ...
Staphylococcus aureus is a normal skin commensal and an opportunistic pathogen that presents serious threat to healthcare. It is the causative agent of septicaemia and... -
Nanosuspsomicroemulsions: nanosuspension stabilty
At Kings College London we have recently developed a novel combination formulation, a nanosuspsomicroemulsion (NSME), comprising of a microemulsion (ME) containing one drug and... -
Investigation of Folded Globular Maltose Binding Protein Based Hydrogels
We have developed a new model to describe the structural architecture of hydrogels composed of cross-linked maltose binding proteins (MBP), supported by multiple techniques... -
Purothionin binding to model fungal lipid membranes
Thionins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of phytopathogenic fungi, and can... -
Microscopic interactions between water and urea and a beta-turn forming peptide
The mechanisms by which proteins fold and unfold in aqueous solutions is still not well understood. Depsite urea being a common protein denaturant, there is no atomic level... -
Does Deuteration Change More then the Phonon Spectrum?
Our recent express measurments on protonated and deuterated 7,7,8,8-tetracyanoquinodimethane (TCNQ) have highlighted some interesting differences between the two. We seek to... -
Elucidating the interaction mechanism of novel antimicrobial dendrimer on rec...
Antimicrobial drug resistance is an increasing problem worldwide. The prospect of exploiting dendritic structures as scaffolds for antimicrobial peptide (AMP) based agents with... -
Structural evolution of self-assembled cyclic-peptide hydrogels
Cyclic peptides which can self-assemble into long nanotubes provide unique properties which can be tailored for a diverse range of biomedical applications. Recently, we have... -
The origins of Biosurfactant self assembly
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Nanoarchitecture of folded maltose binding protein hydrogels
Proteins are the workhorses of the cell, performing a huge array of functions from providing mechanical strength to molecular recognition & binding. They perform these... -
Introducing the O-antigen in Bacterial Outer Membrane in vitro Models Pt. II ...
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
Lysozyme Functionalised Titania: A Kinetic & Structural Optimisation
Hospital-acquired infections of medical devices result in approximately 100,000 deaths each year in the US alone, it is therefore a priority to tackle this. To this end, we have... -
Antibiotic Interactions with models of the Gram negative bacterial outer memb...
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