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Molecular architecture of novel, trichain-containing vectors for gene delivery
We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first... -
Solventless protein liquids: a novel form of biological matter
Solventless protein liquids (SPLS) represent a novel form of biological matter. Recently we reported on the preparation and properties of a solvent-free liquid protein based on... -
Gelatin scaffolds from marine species: Physical gels and enzymatically cross-...
Hydrogels from biopolymers are attracting increasing attention for a range of biomedical applications, but the lack of structural understanding hinders the development of new... -
Study of the interaction of various LPSs with Lactoferrin.
Proposal is focused on the study of the interactions of some lypopolysaccharides (LPSs) with Lactoferrin. LPSs compose about 70-80% of the outer membrane of Gram negative... -
Search for magnetic domains in frustrated magnet CaFe2O4
We propose to study the temperature dependence of the size and shape of the magnetic domains believed to exist in CaFe2O4 - a frustrated triangular antiferromagnet. Our diffuse... -
Effect of reversing lipid head group charge on vesicular properties
Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic... -
Kinetics of the formation of eumelanin and its intermediates
The proposed research project is targeted to the investigation of the characteristics of eumelanin, a heterogeneous material insoluble in water and in any organic solvent, as... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
Lipopolysaccharides are amphiphilic macromolecules indispensable for the growth and the survival of Gram-negative bacteria, one of the most diffuse classes of pathogenic... -
Phase Behaviour of Colloidal Mixtures Under Shear
There are specific models about the influence of shear on mixtures that are distinctive from dspersions of unifom particles. Understanding the flow behaviour of mixtures of... -
Probing membrane localisation of molecular rotors (SANS)
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Reversible folding-unfolding and structural study in protein-ionic liquid sys...
It has been recently shown that reversible thermal folding-unfolding, stabilization and high solubility of proteins (e.g. lysozyme) can be achieved when dissolved in protic...